Lymphoma - Non B cell neoplasms - Primary effusion T cell lymphoma

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Lymphoma - Non B cell neoplasms

T/NK cell disorders

Primary effusion T cell lymphoma

Reviewer: Dragos Luca, M.D. (see Reviewers page)
Revised: 26 October 2011, last major update August 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.

Epidemiology
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● Rare, only a few cases reported

Etiology
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● Also HHV8 associated (like B cell PEL, Cancer 2007;111:224)
● Often in HIV+ patients

Case reports
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● 27 year old woman with post-transplant peritoneal lymphoma not associated with HHV8 or HIV (Pathol Oncol Res 2005;11:178)
● 33 year old HIV+ man with probable genotypic infidelity (Arch Pathol Lab Med 1999;123:257)
● 87 year old man, HHV8+, HIV- (Arch Pathol Lab Med 2001;125:1246)

Micro images
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Various images

Cytology images
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Cytology and cell block

Positive stains
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● CD2, CD3, CD5, CD7

Negative stains
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● CD19, CD20, CD79a, CD138

Genetics and Molecular
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● Clonal TCR gene rearrangements (note that this can occur also in B cell PEL, due to genotypic infidelity)
● No clonal IgH gene rearrangement

Molecular images
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PCR for T cell receptor

PCR for HHV8

End of Lymphoma - Non B cell neoplasms > T/NK cell disorders > Primary effusion T cell lymphoma

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