Lymphoma - Non B cell neoplasms
T/NK cell disorders
Nodal CD8+ cytotoxic T-cell lymphoma
Reviewer: Dragos Luca, M.D. (see Reviewers page)
Revised: 27 October 2011, last major update August 2011
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● These lymphomas are often of Lennert (lymphoepithelioid) type (Virchows Arch 2004;445:334)
● With fulminant clinical course
(Int J Hematol 1999;70:105)
Treatment and prognosis
● Poor prognosis - diffuse large cell type with massive necrosis, apoptosis, DIC or hemophagocytic syndrome (Mod Pathol 2002;15:1131)
● Better prognosis - diffuse medium or mixed cell type
Postulated normal counterpart
● CD8-positive cytotoxic T-lymphocytes
Macrophages ingesting nuclear debris
Diffuse small, medium and large cleaved cells
EBER1+ in situ hybridization
● CD3, CD8, perforin, granzyme B, TIA1, EBV (EBER by ISH)
● CD15, CD30, CD56, may lose CD5 or CD7
End of Lymphoma - Non B cell neoplasms > T/NK cell disorders > Nodal CD8+ cytotoxic T-cell lymphoma
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