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Lymphoma - Non B cell neoplasms

T/NK cell disorders

Nodal CD8+ cytotoxic T-cell lymphoma


Reviewer: Dragos Luca, M.D. (see Reviewers page)
Revised: 27 October 2011, last major update August 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.

Terminology
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● These lymphomas are often of Lennert (lymphoepithelioid) type (Virchows Arch 2004;445:334)

Case reports
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● With fulminant clinical course (Int J Hematol 1999;70:105)

Treatment and prognosis
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● Poor prognosis - diffuse large cell type with massive necrosis, apoptosis, DIC or hemophagocytic syndrome (Mod Pathol 2002;15:1131)
● Better prognosis - diffuse medium or mixed cell type

Postulated normal counterpart
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● CD8-positive cytotoxic T-lymphocytes

Micro images
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Macrophages ingesting nuclear debris

   
Diffuse small, medium and large cleaved cells


CD3+


CD8+


Perforin+


Granzyme B+


TIA1+


EBER1+ in situ hybridization

Positive stains
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● CD3, CD8, perforin, granzyme B, TIA1, EBV (EBER by ISH)

Negative stains
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● CD15, CD30, CD56, may lose CD5 or CD7

End of Lymphoma - Non B cell neoplasms > T/NK cell disorders > Nodal CD8+ cytotoxic T-cell lymphoma


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