Lymphoma - B cell neoplasms - Normal lymphocyte development

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Lymphoma - B cell neoplasms

Lymph nodes

Normal lymphocyte development-general

Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 26 December 2010, last major update December 2010
Copyright: (c) 2001-2010, PathologyOutlines.com, Inc.

General
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● Normal lymphoid cells undergo rearrangements within their antigen receptor genes, causing specificity for the immunoglobulin or T cell receptor that they produce
● Monoclonal proliferations are presumed to be neoplastic; polyclonal populations are not neoplastic
● Apoptosis helps eliminate B cells producing antibodies with low avidity

Pluripotent hematopoietic cell / stem cell
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● All hematopoietic cells, including lymphocytes, arise from a single pluripotent hematopoietic cell, which has properties of self-renewal and potency (Wikipedia)
● Self-renewal: the ability to go through numerous cycles of cell division while maintaining the undifferentiated state
● Potency: the capacity to differentiate into specialized cell types (cells of erythroid, megakaryocytic, myeloid and lymphoid lineages)
● Upon transplantation, can home back to appropriate sites in the bone marrow with retention of above properties
● Lymphoid stem cells are TdT+, CD34+, HLA-DR+

Diagrams
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Hematopoiesis diagrams

End of Lymphoma - B cell neoplasms > Lymph nodes > Normal lymphocyte development-general

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