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Lymphoma - B cell neoplasms

Plasma cell neoplasms - general


Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 13 March 2011, last major update March 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.

Definition
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● Various disorders characterized by monoclonal proliferation of immunoglobulin producing cells resembling lymphocytes or plasma cells

Terminology
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● Monoclonal immunoglobulin (Ig) is also referred to as M component or as a paraprotein
● Bence Jones proteins: free light chains without attached heavy chains

Clinical features
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● Detect as monoclonal peak on serum or urine electrophoresis

WHO classification of plasma cell neoplasms (2008)
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● Plasma cell myeloma
● Plasmacytoma
● Monoclonal immunoglobulin deposition diseases
● Monoclonal gammopathy of undetermined significance (MGUS)
● Osteosclerotic myeloma (POEMS syndrome)

End of Lymphoma - B cell neoplasms > Plasma cell neoplasms - General


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