Lymphoma and plasma cell neoplasms
Plasma cell neoplasms
General

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 3 April 2017, last major update March 2011

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PubMed Search: plasma cell neoplasms lymphoma

Cite this page: Plasma cell neoplasms - General. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphomaplasmacellgeneral.html. Accessed November 19th, 2017.
Definition / general
  • Various disorders characterized by monoclonal proliferation of immunoglobulin producing cells resembling lymphocytes or plasma cells
Terminology
  • Monoclonal immunoglobulin (Ig) is also referred to as "M" component or as a paraprotein
  • Bence Jones proteins: free light chains without attached heavy chains
Clinical features
  • Detect as monoclonal peak on serum or urine electrophoresis
WHO Classification (2008)
  • Plasma cell myeloma
  • Plasmacytoma
  • Monoclonal immunoglobulin deposition diseases
  • Monoclonal gammopathy of undetermined significance (MGUS)
  • Osteosclerotic myeloma (POEMS syndrome)