Lymphoma and plasma cell neoplasms
Plasma cell neoplasms

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 3 April 2017, last major update March 2011

Copyright: (c) 2001-2017,, Inc.

PubMed Search: plasma cell neoplasms lymphoma

Cite this page: Plasma cell neoplasms - General. website. Accessed October 18th, 2018.
Definition / general
  • Various disorders characterized by monoclonal proliferation of immunoglobulin producing cells resembling lymphocytes or plasma cells
  • Monoclonal immunoglobulin (Ig) is also referred to as "M" component or as a paraprotein
  • Bence Jones proteins: free light chains without attached heavy chains
Clinical features
  • Detect as monoclonal peak on serum or urine electrophoresis
WHO Classification (2008)
  • Plasma cell myeloma
  • Plasmacytoma
  • Monoclonal immunoglobulin deposition diseases
  • Monoclonal gammopathy of undetermined significance (MGUS)
  • Osteosclerotic myeloma (POEMS syndrome)