Bone marrow neoplastic
Bone marrow - plasma cell and lymphoid neoplasms
Plasma cell neoplasms
Plasma cell neoplasms - General

Topic Completed: 1 March 2011

Minor changes: 6 March 2020

Copyright: 2001-2020,, Inc.

PubMed Search: plasma cell neoplasms lymphoma

Nikhil Sangle, M.D.
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Cite this page: Sangle N. Plasma cell neoplasms - General. website. Accessed August 10th, 2020.
Definition / general
  • Various disorders characterized by monoclonal proliferation of immunoglobulin producing cells resembling lymphocytes or plasma cells
  • Monoclonal immunoglobulin (Ig) is also referred to as "M" component or as a paraprotein
  • Bence Jones proteins: free light chains without attached heavy chains
Clinical features
  • Detect as monoclonal peak on serum or urine electrophoresis
WHO Classification (2008)
  • Plasma cell myeloma
  • Plasmacytoma
  • Monoclonal immunoglobulin deposition diseases
  • Monoclonal gammopathy of undetermined significance (MGUS)
  • Osteosclerotic myeloma (POEMS syndrome)
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