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Lymphoma - B cell neoplasms

B cell lymphoma subtypes

Primary cutaneous diffuse large B-cell lymphoma - Leg


Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 16 July 2011, last major update March 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.

Clinical features
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● 5-10% of primary cutaneous diffuse large B cell lymphomas cases
● Usually elderly patients
● May have poorer prognosis than at other cutaneous sites (Am J Surg Path 2003;27:1538), although somewhat controversial (Hum Pathol 2002;33:937)

Case reports
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● 52 year old man with skin lesion on back for two years (Case Rep Dermatol 2009;1:87)

Clinical images
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Plaque on back

Gross description
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● Solitary or grouped red/blue nodules

Micro description
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● Dense, diffuse large cells infiltrating entire dermis
● Cells resemble immunoblasts (large oval vesicular nuclei with prominent nucleoli) or centroblasts (large noncleaved nuclei, prominent nucleoli)
● Usually thin Grenz zone

End of Lymphoma - B cell neoplasms > B cell lymphoma subtypes > Primary cutaneous diffuse large B-cell lymphoma - Leg


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