Mandible & maxilla
Benign tumors / tumor-like conditions
Calcifying epithelial odontogenic tumor

Topic Completed: 1 October 2013

Minor changes: 15 November 2019

Copyright: 2004-2019,, Inc.

PubMed Search: Calcifying epithelial odontogenic tumor [title]

Nat Pernick, M.D.
Page views in 2019: 2,529
Page views in 2020 to date: 1,243
Cite this page: Pernick N. Benign tumors / tumor-like conditions: calcifying epithelial odontogenic tumor. website. Accessed May 31st, 2020.
Definition / general
  • Also called Pindborg tumor
  • Rare
  • Ages 30 - 49 years
  • May also occur within gingiva (peripheral tumor)
  • May be invasive and recur locally, but less aggressive than ameloblastoma
  • Premolar mandible
  • Often associated with embedded tooth
Radiology description
  • Resembles dentigerous cyst with occasional small radiopacities within large radiolucent area
  • Less aggressive than ameloblastoma
Case reports
Microscopic (histologic) description
  • Sheets of polyhedral, eosinophilic squamous epithelial cells with focal psammoma bodies
  • Variable markedly pleomorphic cells with 2 - 3 nuclei
  • Amyloid bodies (containing degenerated keratin filaments)
  • Often scanty stroma, although epithelium / stromal ratio is variable between tumors
  • Clear cell variant has clear vacuolated cytoplasm
Microscopic (histologic) images

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Characterized by squamous epithelial cells

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Stained positively for cytokeratins

Positive stains
Electron microscopy images

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Large fibrillary deposit

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