Mandible / maxilla
Other inflammatory
Central giant cell granuloma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 21 June 2018, last major update October 2013

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Central giant cell granuloma [title]

Cite this page: Pernick, N. Other inflammatory: central giant cell granuloma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mandiblemaxillacentralgiantcellgranuloma.html. Accessed August 16th, 2018.
Definition / general
  • Also called giant cell reparative granuloma
  • Central if intraosseous; peripheral if extraosseous
  • May be due to recurrent slow, minute hemorrhages
  • Often associated with trauma
  • Children and young adults, usually females
  • Lesion appears to be unique to jaw
  • Usually anterior mandible
Radiology description
  • Radiolucent, multilocular lesion, may have resorption / movement of teeth and penetration of jaw cortex
Treatment
  • Excision, thorough curettage
  • May recur
Gross description
  • Cystic bone lesion
Microscopic (histologic) description
  • Numerous osteoclast-like giant cells near hemorrhagic areas, cellular vascular and fibrous stroma, new bone formation at edge of lesion
  • Frequent mitotic figures
  • No necrosis
Positive stains
  • CD68 (giant cells)
Electron microscopy description
  • Fibroblasts, myofibroblasts, histiocytes