Mandible / maxilla
Benign tumors / tumor-like conditions
Desmoplastic fibroma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 21 June 2018, last major update October 2013

Copyright: (c) 2004-2018,, Inc.

PubMed Search: Desmoplastic fibroma [title]

Cite this page: Pernick, N. Benign tumors / tumor-like conditions: desmoplastic fibroma. website. Accessed December 17th, 2018.
Definition / general
  • Rare, mean 23 years, range 1 - 75 years
  • Intraosseous component of soft tissue fibromatosis
  • May be due to local trauma; may be part of Gardner syndrome
  • Benign, but up to 35% recur, does not metastasize
Case reports
  • Wide local excision
Clinical images

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Figure 1: CT scan

Gross description
  • Firm, rubbery, white, nonencapsulated, fibrous appearing lesion
Microscopic (histologic) description
  • Poorly demarcated lesion with interlacing or fascicular pattern of mature fibrous tissue composed of small fibroblasts with no / minimal mitotic activity and abundant collagenous stroma
  • No osteoid, no epithelial rests, rare multinucleated giant cells
Microscopic (histologic) images

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Figure 2/3: spindled lesion with fibromyxoid stroma

Positive stains
Negative stains