Mandible & maxilla
Other inflammatory
Peripheral giant cell granuloma

Topic Completed: 1 October 2013

Minor changes: 27 November 2019

Copyright: 2004-2019,, Inc.

PubMed Search: Peripheral giant cell granuloma [title]

Nat Pernick, M.D.
Page views in 2019: 925
Page views in 2020 to date: 359
Cite this page: Pernick N. Other inflammatory: peripheral giant cell granuloma. website. Accessed May 27th, 2020.
Definition / general
  • Also called giant cell epulis
  • Resembles pyogenic granuloma but may erode alveolar bone or involve periodontal membrane
  • Usually women, mean age 30 years, although may involve children or elderly patients without teeth
  • May be due to trauma, local irritation or chronic infection
  • Recurs if not completely excised
  • Excision with curettage of base of lesion extending into adjacent periodontal membrane
Gross description
  • Inflammatory lesion up to 1.5 cm that protrudes from gingiva at site of chronic inflammation
  • Covered by gingival mucosa or ulcerated
Microscopic (histologic) description
  • Nonencapsulated aggregates of foreign body giant cells and fibroangiomatous stroma with hemorrhage, hemosiderin, acute and chronic inflammatory cells
  • Alveolar bone often expanded in edentulous patients leading to superficial bone loss with peripheral cuffing
Differential diagnosis
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