Mandible / maxilla
Other inflammatory
Peripheral giant cell granuloma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 21 June 2018, last major update October 2013

Copyright: (c) 2004-2018,, Inc.

PubMed Search: Peripheral giant cell granuloma [title]

Cite this page: Pernick, N. Other inflammatory: peripheral giant cell granuloma. website. Accessed July 21st, 2018.
Definition / general
  • Also called giant cell epulis
  • Resembles pyogenic granuloma but may erode alveolar bone or involve periodontal membrane
  • Usually women, mean age 30 years, although may involve children or elderly patients without teeth
  • May be due to trauma, local irritation or chronic infection
  • Recurs if not completely excised
  • Excision with curettage of base of lesion extending into adjacent periodontal membrane
Gross description
  • Inflammatory lesion up to 1.5 cm that protrudes from gingiva at site of chronic inflammation
  • Covered by gingival mucosa or ulcerated
Microscopic (histologic) description
  • Nonencapsulated aggregates of foreign body giant cells and fibroangiomatous stroma with hemorrhage, hemosiderin, acute and chronic inflammatory cells
  • Alveolar bone often expanded in edentulous patients leading to superficial bone loss with peripheral cuffing
Differential diagnosis