Mandible / maxilla
Malignant tumors
Primary intraosseous carcinoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 21 June 2018, last major update November 2013

Copyright: (c) 2004-2018,, Inc.

PubMed Search: Primary intraosseous carcinoma

Cite this page: Pernick, N. Malignant tumors: primary intraosseous carcinoma. website. Accessed July 22nd, 2018.
Definition / general
  • May arise from epithelial lining of an odontogenic cyst or de novo from intraosseous odontogenic rests
  • Mean age is 52 years (range 4 to 76 years); 70% occur in men (Int J Oral Maxillofac Surg 2001;30:349); most tumors (92%) occur in mandible
  • Progressive swelling of the jaw, pain and loosening of the teeth
  • Cervical nodal metastases are common
  • Aggressive behavior (4 year survival is 40%)
Radiology description
  • Radiolucent cystic-like pattern of bone destruction but with well defined margins
Radiology images

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Lytic and cystic lesion involving right mandible

Case reports
Microscopic (histologic) description
  • Usually squamous cell carcinoma, high grade
Microscopic (histologic) images

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Verrucous carcinoma

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Cyst lining with chronic inflammation