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Mandible & maxilla

Malignant odontogenic tumors

Primary intraosseous carcinoma, NOS

Author: Nat Pernick, M.D.

Last author update: 1 November 2013

Last staff update: 6 December 2021

Copyright: 2004-2024, PathologyOutlines.com, Inc.

PubMed Search: Primary intraosseous carcinoma [title]

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Table of Contents

Cite this page: Pernick N. Primary intraosseous carcinoma, NOS. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/mandiblemaxillaprimaryintraosseouscarcinoma.html. Accessed April 19th, 2024.

Definition / general

May arise from epithelial lining of an odontogenic cyst or de novo from intraosseous odontogenic rests
Mean age is 52 years (range 4 to 76 years); 70% occur in men (Int J Oral Maxillofac Surg 2001;30:349); most tumors (92%) occur in mandible
Progressive swelling of the jaw, pain and loosening of the teeth
Cervical nodal metastases are common
Aggressive behavior (4 year survival is 40%)

Radiology description

Radiolucent cystic-like pattern of bone destruction but with well defined margins

Radiology images

Images hosted on PathOut server:

Lytic and cystic lesion involving right mandible

Case reports

66 year old man with enlargement of mandible (Case of Week #73)
Primary intraosseous verrucous carcinoma developing from a maxillary odontogenic cyst (Tumori 2001;87:444)
Verrucous carcinoma arising in an odontogenic cyst (Oral Surg Oral Med Oral Pathol 1980;49:151)

Treatment