Cytopathology competency assessment
Lymph node

Topic Completed: 1 September 2012

Revised: 4 January 2019, last major update September 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Mediastinum[TI] cytopathology lymph node[TIAB]

Gordon H. Yu, M.D.
Page views in 2018: 175
Page views in 2019 to date: 159
Cite this page: Yu G. Cytopathology competency assessment - lymph node. website. Accessed August 22nd, 2019.
Medical knowledge, practice based learning and systems based practice
  1. Reactive hyperplasia
    1. Recognize frequently encountered clinical scenarios associated with reactive lymphoid hyperplasia
    2. Become familiar with the typical cytologic smear appearance of a reactive lymphoid proliferation and the differential diagnosis of a lymphoid rich FNA biopsy from a mediastinal mass
  2. Castleman disease (angiofollicular hyperplasia)
    1. Learn the typical clinical and radiologic presentation of Castleman disease, its clinical course and other potential anatomic locations
    2. Learn the two major subtypes of Castleman Disease
      1. Hyaline vascular type
        • Become familiar with the clinical presentation of this subtype (lack of systemic symptoms)
        • Become familiar with the typical histologic features of this lesion and correlate it to potential FNA findings
      2. Plasma cell type
        • Recognize the frequent association of this subtype with systemic symptoms and its association with other clinical syndromes
        • Become familiar with typical FNA findings and its differential diagnosis
  3. Lymphoma
    1. Recognize that lymphoma represents the most common primary neoplasm of the middle mediastinum as well as its frequent occurrence in other compartments of the mediastinum
    2. Recognize the diagnostic utility of FNA biopsy in the diagnosis of lymphoma, as well as histologic features which may interfere with the consistent acquisition of diagnostic material
      1. Hodgkin lymphoma
        • Recognize Hodgkin lymphoma as the most common primary mediastinal lymphoma
        • Become familiar with the typical morphologic features of FNA biopsy of this tumor and the differential diagnoses which must be considered
        • Identify useful immunohistochemical stains to exclude other potential entities when making this diagnosis
      2. Non-Hodgkin lymphoma
        • Become familiar with the expected FNA findings of primary mediastinal large B cell lymphoma as well as its expected immunohistochemical staining pattern based on its cell of origin
        • Become familiar with the typical FNA findings of lymphoblastic lymphoma, including background features typically seen as a result of its rapid growth and cell turnover
        • Learn the expected FNA features of thymic MALToma and its expected immunohistochemical staining pattern
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