Mediastinum
Thymic carcinoma
Lymphoepithelioma-like thymic carcinoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 19 June 2018, last major update December 2012

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PubMed Search: Lymphoepithelioma-like thymic carcinoma

Cite this page: Gulwani, H. Lymphoepithelioma-like thymic carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumLEL.html. Accessed July 21st, 2018.
Definition / general
  • Type of poorly differentiated squamous cell carcinoma
  • Almost always fatal
Case reports
Microscopic (histologic) description
  • Syncytial groups of large, anaplastic, polyhedral cells with indistinct cell boundaries, amphophilic cytoplasm, round / oval vesicular nuclei, prominent eosinophilic nucleoli, mixed with mature lymphocytes
  • Micronodular growth pattern in stroma showing florid lymphoid hyperplasia; epithelial cell component shows unequivocal signs of malignancy characterized by cytological atypia and increased mitotic activity (Mod Pathol 2012;25:993)
  • Brisk mitotic activity, narrow fibrovascular septae, variable necrosis
Microscopic (histologic) images

Images hosted on other servers:

Syncytial epithelial cells and T cells

Large, round, vesicular nuclei with prominent nucleoli

Positive stains
Large tumor cells:
Negative stains
Large tumor cells: