Other malignancies

Topic Completed: 1 December 2012

Revised: 14 February 2019

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Leiomyosarcoma mediastinum

Hanni Gulwani, M.B.B.S.
Page views in 2018: 27
Page views in 2019 to date: 58
Cite this page: Gulwani H. Leiomyosarcoma. website. Accessed September 23rd, 2019.
  • Ages 25 - 70
Case reports
Gross description
  • Circumscribed, tan-white, firm, with cystic or myxoid degeneration
Microscopic (histologic) description
  • Smooth muscle in fascicles with moderate to marked atypia and frequent mitotic activity
  • Often epithelioid cells
Microscopic (histologic) images

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Cigar shaped spindle cells are smooth muscle actin+

Negative stains
Electron microscopy description
  • Epithelioid tumors have plasmalemmal dense patches, pinocytotic activity, basal lamina, thin cytoplasmic filaments, dense bodies
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