Soft tissue lesions

Topic Completed: 1 December 2012

Minor changes: 4 December 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Leiomyosarcoma mediastinum

Hanni Gulwani, M.B.B.S.
Page views in 2019: 81
Page views in 2020 to date: 56
Cite this page: Gulwani H. Leiomyosarcoma. website. Accessed May 30th, 2020.
  • Ages 25 - 70
Case reports
Gross description
  • Circumscribed, tan-white, firm, with cystic or myxoid degeneration
Microscopic (histologic) description
  • Smooth muscle in fascicles with moderate to marked atypia and frequent mitotic activity
  • Often epithelioid cells
Microscopic (histologic) images

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Cigar shaped spindle cells are smooth muscle actin+

Negative stains
Electron microscopy description
  • Epithelioid tumors have plasmalemmal dense patches, pinocytotic activity, basal lamina, thin cytoplasmic filaments, dense bodies
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