Other malignancies

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 21 June 2018, last major update December 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Leiomyosarcoma mediastinum

Cite this page: Gulwani, H. Leiomyosarcoma. website. Accessed July 21st, 2018.
  • Ages 25 - 70
Case reports
Gross description
  • Circumscribed, tan-white, firm, with cystic or myxoid degeneration
Microscopic (histologic) description
  • Smooth muscle in fascicles with moderate to marked atypia and frequent mitotic activity
  • Often epithelioid cells
Microscopic (histologic) images

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Cigar shaped spindle cells are smooth muscle actin+

Negative stains
Electron microscopy description
  • Epithelioid tumors have plasmalemmal dense patches, pinocytotic activity, basal lamina, thin cytoplasmic filaments, dense bodies