Hematological neoplasms / lesions
NK lymphoma

Topic Completed: 1 December 2012

Revised: 14 February 2019

Copyright: 2003-2018,, Inc.

PubMed Search: NK lymphoma mediastinum

Hanni Gulwani, M.B.B.S.
Page views in 2018: 67
Page views in 2019 to date: 265
Cite this page: Gulwani H. NK lymphoma. website. Accessed November 13th, 2019.
  • Rare in nonnasal locations
Clinical features
  • Characterized by cutaneous, nodal and marrow involvement by blastic cells with immunophenotypic characteristics of true NK cells; afflicts elderly patients, pursues an aggressive course and may culminate in overt leukemia (Am J Surg Pathol 1997;21:1223)
Case reports
Microscopic (histologic) description
  • Diffuse dense infiltrate of atypical intermediate to large lymphoid cells and occasional immunoblasts, with angiocentric and angiodestructive growth and extensive necrosis
  • Azurophilic granules with Giemsa stain
Microscopic (histologic) images

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lymphocytes with

CD3, granzyme, TIA1

Positive stains
Electron microscopy description
  • Dense cytoplasmic granules
Electron microscopy images

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Cytoplasmic dense core granules

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