Mediastinum
Hematological neoplasms / lesions
NK lymphoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 20 June 2018, last major update December 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: NK lymphoma mediastinum

Cite this page: Gulwani, H. NK lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumNKlymphoma.html. Accessed July 21st, 2018.
Sites
  • Rare in nonnasal locations
Clinical features
  • Characterized by cutaneous, nodal and marrow involvement by blastic cells with immunophenotypic characteristics of true NK cells; afflicts elderly patients, pursues an aggressive course and may culminate in overt leukemia (Am J Surg Pathol 1997;21:1223)
Case reports
Microscopic (histologic) description
  • Diffuse dense infiltrate of atypical intermediate to large lymphoid cells and occasional immunoblasts, with angiocentric and angiodestructive growth and extensive necrosis
  • Azurophilic granules with Giemsa stain
Microscopic (histologic) images

Images hosted on other servers:

Atypical
lymphocytes with
angioinvasive
lesions

CD3, granzyme, TIA1

Positive stains
Electron microscopy description
  • Dense cytoplasmic granules
Electron microscopy images

Images hosted on other servers:

Cytoplasmic dense core granules