Mediastinum
Thymic carcinoma
Parathyroid carcinoma of thymus




Topic Completed: 1 December 2012

Revised: 14 February 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Parathyroid carcinoma of thymus[TIAB]

Page views in 2018: 75
Page views in 2019 to date: 60
Cite this page: Gulwani H. Parathyroid carcinoma of thymus. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumPTH.html. Accessed May 21st, 2019.
Definition / general
  • May arise within thymus or adjacent soft tissue of anterosuperior mediastinum
Clinical features
  • Usually extreme hypercalcemia (> 14 mg/dl), markedly elevated parathyroid hormone (PTH) levels
Poor prognostic factors
  • > 5 MF/HPF, thick fibrous capsule or infiltrative growth pattern
Case reports
Gross description
  • Resembles primary thymic carcinoma
  • May invade adjacent lung, pericardium, thoracic great vessels
  • Unencapsulated
Microscopic (histologic) description
  • Modest to marked atypia
  • Sheets, nests or cords of polyhedral cells with round / oval hyperchromatic nuclei, occasional nucleoli, clear / granular cytoplasm
  • Focal mitotic activity, necrosis
  • May have internal collagenous bands
Microscopic (histologic) images

Images hosted on other servers:

Parathyroid carcinoma: site unknown

Positive stains
Electron microscopy description
  • Primitive intercellular junctional complexes, prominent cytoplasmic glycogen, primitive blunt microvilli, sparse neurosecretory granules
  • No tonofilaments
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