Mediastinum
Thymic carcinoma
Parathyroid carcinoma of thymus

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 19 June 2018, last major update December 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Parathyroid carcinoma of thymus[TIAB]

Cite this page: Gulwani, H. Parathyroid carcinoma of thymus. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumPTH.html. Accessed July 19th, 2018.
Definition / general
  • May arise within thymus or adjacent soft tissue of anterosuperior mediastinum
Clinical features
  • Usually extreme hypercalcemia (> 14 mg/dl), markedly elevated parathyroid hormone (PTH) levels
Poor prognostic factors
  • > 5 MF/HPF, thick fibrous capsule or infiltrative growth pattern
Case reports
Gross description
  • Resembles primary thymic carcinoma
  • May invade adjacent lung, pericardium, thoracic great vessels
  • Unencapsulated
Microscopic (histologic) description
  • Modest to marked atypia
  • Sheets, nests or cords of polyhedral cells with round / oval hyperchromatic nuclei, occasional nucleoli, clear / granular cytoplasm
  • Focal mitotic activity, necrosis
  • May have internal collagenous bands
Microscopic (histologic) images

Images hosted on other servers:

Parathyroid carcinoma: site unknown

Positive stains
Electron microscopy description
  • Primitive intercellular junctional complexes, prominent cytoplasmic glycogen, primitive blunt microvilli, sparse neurosecretory granules
  • No tonofilaments