Mediastinum - Adenocarcinoma of thymus, NOS

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Mediastinum

Thymic carcinoma

Adenocarcinoma of thymus, NOS

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 3 March 2013, last major update December 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Rare, <10 cases reported
● Most common type is papillary, mucinous subtype also reported

Epidemiology
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● Mean age 50 years, but wide range

Clinical features
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● Must rule out metastatic tumor
● More likely to be thymic primary if CD5+ and transition from thymoma or thymic cyst to adenocarcinoma is present
● Outcome is highly variable

Case reports
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● 15 year old with mucinous adenocarcinoma and 39 year old with papillary adenocarcinoma (Am J Surg Pathol 2003;27:124)
● 41 year old man with primary mucinous adenocarcinoma (Arch Pathol Lab Med 2006;130:201)
● 59 year old man with tumor demonstrating papillary, acinar and cribriform structure, and which produced abundant extracellular mucin (Hum Pathol 2005;36:219)
● 61 year old woman with tumor with numerous psammoma bodies and 82 year old woman with case arising from thymic cyst with areas of transition from benign to dysplastic epithelium (Am J Surg Pathol 2007;31:1330)
● Tubular adenocarcinoma (Int J Surg Pathol 2006;14:243)

Micro images
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Mucinous adenocarcinoma of the thymus

End of Mediastinum > Thymic carcinoma > Adenocarcinoma of thymus, NOS

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