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Mediastinum
Thymic carcinoma
Anaplastic thymic carcinoma
Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 3 March 2013, last major update December 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
General
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● Undifferentiated thymic carcinoma
● Symptoms related to anterior mediastinal masses: shortness of breath, chest pain, and cough
Epidemiology
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● More common in women
● Age range 42-72 years
Clinical features
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● Aggressive clinical course
Micro description
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● Infiltrative with marked cytologic atypia, bizarre tumor giant cells, and atypical mitoses; no areas of other well-defined types of thymic carcinoma (Hum Pathol 2012;43:874)
Micro images
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No appreciable differentiation toward any specific type
Positive stains
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● Pancytokeratin, PAX8 (40%)
Negative stains
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● TTF1
End of Mediastinum > Thymic carcinoma > Anaplastic thymic carcinoma
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