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Mediastinum

Other benign / low grade tumors

Angiomyolipoma

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 3 March 2013, last major update December 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Benign tumor, common in kidney, rare in mediastinum

Clinical features
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● May arise in setting of tuberous sclerosis complex

Case reports
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● Angiomyolipomas in mediastinum and lung, possibly associated with lymphangioleiomyomatosis and tuberous sclerosis complex (J Thorac Imaging 2012;27:W21)
● Incidentally discovered angiomyolipoma in the anterior mediastinum (Ann Diagn Pathol 2008;12:293)

Gross images
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Large fatty anterior mediastinal mass

Micro description
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● Composed of varying proportions of smooth muscle cells, blood vessels, and adipose tissue

Micro images
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Confluencing vessel lumina partly filled with blood (right) and interstitial stroma containing mostly smooth muscle cells and focal fat cells

Positive stains
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● IHC: positive for smooth muscle actin and HMB-45.

End of Mediastinum > Other benign / low grade tumors > Angiomyolipoma

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