Basaloid squamous cell carcinoma
Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 3 March 2013, last major update December 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Primary thymic tumor or metastatic tumor to mediastinum from oropharynx, hypopharynx, larynx, esophagus, lung, anorectum
● Present with intrathoracic mass
● Primary tumors are associated with multilocular thymic cysts
● Capable of aggressive behavior and significant mortality (Am J Surg Pathol 2009;33:1113)
● Good prognosis with few fatalities if well differentiated
● Nests, cords and sheets of small polygonal cells with minimal cytoplasm, hyperchromatic round nuclei, abundant mitotic figures
● No nuclear molding
● Separated by myxoid or eosinophilic stroma
● May have peripheral pallisading of nuclei
● May have areas of squamous differentiation with keratin pearls, or stromal mucin containing gland-like profiles
● May have cystic structures
Prominent peripheral palisading
● CD117, EMA, keratin
● Neuroendocrine markers
Electron microscopy description
● Poorly differentiated squamous proliferation with limited cytoplasmic tonofilaments, well-formed desmosomes, redundant basal lamina
● No neurosecretory granules
End of Mediastinum > Thymic carcinoma > Basaloid squamous cell carcinoma
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