Mediastinum
Thymic carcinoma
Basaloid squamous cell carcinoma




Topic Completed: 1 December 2012

Revised: 13 February 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Basaloid squamous cell carcinoma[TI]

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Cite this page: Gulwani H. Basaloid squamous cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumbasaloidscc.html. Accessed May 22nd, 2019.
Definition / general
  • Primary thymic tumor or metastatic tumor to mediastinum from oropharynx, hypopharynx, larynx, esophagus, lung, anorectum
Clinical features
  • Present with intrathoracic mass
  • Primary tumors are associated with multilocular thymic cysts
  • Capable of aggressive behavior and significant mortality (Am J Surg Pathol 2009;33:1113)
Prognostic factors
  • Good prognosis with few fatalities if well differentiated
Microscopic (histologic) description
  • Nests, cords and sheets of small polygonal cells with minimal cytoplasm, hyperchromatic round nuclei, abundant mitotic figures
  • No nuclear molding
  • Separated by myxoid or eosinophilic stroma
  • May have peripheral pallisading of nuclei
  • May have areas of squamous differentiation with keratin pearls or stromal mucin containing gland-like profiles
  • May have cystic structures
Microscopic (histologic) images

Images hosted on other servers:

Prominent peripheral palisading

Positive stains
Negative stains
  • Neuroendocrine markers
Electron microscopy description
  • Poorly differentiated squamous proliferation with limited cytoplasmic tonofilaments, well formed desmosomes, redundant basal lamina
  • No neurosecretory granules
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