Mediastinum
Hematological neoplasms / lesions
Burkitt lymphoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 20 June 2018, last major update December 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Burkitt lymphoma mediastinum

Cite this page: Gulwani, H. Burkitt lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumburkitt.html. Accessed August 19th, 2018.
Terminology
  • Also called small noncleaved cell lymphoma
Epidemiology
  • Usually children / teens
Sites
  • May arise in mediastinum without disease elsewhere
Clinical features
  • Often occurs in HIV+ patients
  • 5 year survival of 50% with multiagent chemotherapy
Case reports
Microscopic (histologic) description
  • Coarsely clumped chromatin, prominent nucleoli, numerous mitotic figures
  • Starry sky appearance due to tingible body macrophages
Microscopic (histologic) images

Images hosted on other servers:

Starry sky pattern: sheets of monomorphic lymphoid cells mixed with large, clear macrophages containing apoptopic debris

Monomorphic blast cells with glandular
nuclear chromatin; cytoplasm is well defined,
amphophilic and contains small lipid vacuoles

Positive stains