Mediastinum
Hematological neoplasms / lesions
Burkitt lymphoma



Topic Completed: 1 December 2012

Revised: 14 February 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Burkitt lymphoma mediastinum


Hanni Gulwani, M.B.B.S.
Page views in 2018: 167
Page views in 2019 to date: 245
Cite this page: Gulwani H. Burkitt lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumburkitt.html. Accessed September 23rd, 2019.
Terminology
  • Also called small noncleaved cell lymphoma
Epidemiology
  • Usually children / teens
Sites
  • May arise in mediastinum without disease elsewhere
Clinical features
  • Often occurs in HIV+ patients
  • 5 year survival of 50% with multiagent chemotherapy
Case reports
Microscopic (histologic) description
  • Coarsely clumped chromatin, prominent nucleoli, numerous mitotic figures
  • Starry sky appearance due to tingible body macrophages
Microscopic (histologic) images

Images hosted on other servers:

Starry sky pattern: sheets of monomorphic lymphoid cells mixed with large, clear macrophages containing apoptopic debris

Monomorphic blast cells with glandular
nuclear chromatin; cytoplasm is well defined,
amphophilic and contains small lipid vacuoles

Positive stains
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