Hematological neoplasms / lesions
Castleman disease

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 20 June 2018, last major update December 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Castleman disease mediastinum

Cite this page: Gulwani, H. Castleman disease. website. Accessed July 19th, 2018.
  • Also called angiofollicular lymphoid hyperplasia, giant lymph node hyperplasia
  • Primarily affects mediastinal lymph nodes, occasionally affects thymus
Clinical features
  • Associated with fever, weight loss, anemia
Prognostic factors
  • Poor prognosis if multifocal disease
Case reports
  • Excision is curative if localized
Clinical images

Images hosted on other servers:

Mediastinal mass

Gross description
  • Enlarged, distorted lymph nodes
Microscopic (histologic) description
  • Follicular aggregates of small, mature lymphocytes with compression of sinuses
  • Increased number of small caliber vessels, surrounded by fibrohyaline eosinophilic material or mature plasma cells
  • Follicles also surrounded by "onion skin" arrays of lymphocytes
Microscopic (histologic) images

Images hosted on other servers:

Vascular proliferation and hyalinization

Broad mantle zone

Onion-like appearance