Hematological neoplasms / lesions
Castleman disease

Topic Completed: 1 December 2012

Revised: 14 February 2019

Copyright: 2003-2018,, Inc.

PubMed Search: Castleman disease mediastinum

Hanni Gulwani, M.B.B.S.
Page views in 2018: 847
Page views in 2019 to date: 982
Cite this page: Gulwani H. Castleman disease. website. Accessed September 23rd, 2019.
  • Also called angiofollicular lymphoid hyperplasia, giant lymph node hyperplasia
  • Primarily affects mediastinal lymph nodes, occasionally affects thymus
Clinical features
  • Associated with fever, weight loss, anemia
Prognostic factors
  • Poor prognosis if multifocal disease
Case reports
  • Excision is curative if localized
Clinical images

Images hosted on other servers:

Mediastinal mass

Gross description
  • Enlarged, distorted lymph nodes
Microscopic (histologic) description
  • Follicular aggregates of small, mature lymphocytes with compression of sinuses
  • Increased number of small caliber vessels, surrounded by fibrohyaline eosinophilic material or mature plasma cells
  • Follicles also surrounded by "onion skin" arrays of lymphocytes
Microscopic (histologic) images

Images hosted on other servers:

Vascular proliferation and hyalinization

Broad mantle zone

Onion-like appearance

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