Other malignancies

Topic Completed: 1 December 2012

Revised: 14 February 2019

Copyright: 2003-2018,, Inc.

PubMed Search: Chordoma mediastinum

Hanni Gulwani, M.B.B.S.
Page views in 2018: 115
Page views in 2019 to date: 200
Cite this page: Gulwani H. Chordoma. website. Accessed September 23rd, 2019.
Definition / general
  • May present as paramedian posterior mediastinal mass in adults or children
  • More common location is base of skull or sacrococcygeal region
Gross description
  • Circumscribed, unencapsulated, with mucoid gray-white cut surface
Microscopic (histologic) description
  • Nests and cords of physaliphorous cells (polygonal with multiple small cytoplasmic vacuoles) with hyperchromatic nuclei, prominent nucleoli), frequent mitotic activity, in myxochondroid matrix (Hum Pathol 1995;26:1354)
Microscopic (histologic) images

Images hosted on other servers:

Abundant, bubbly
cytoplasm is
CK+ (inset)

Positive stains
Electron microscopy description
  • Intercellular junctions, intermediate filaments, rough endoplasmic reticulum complexed to mitochondria
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