Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 17 March 2013, last major update December 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- May present as paramedian posterior mediastinal mass in adults or children
- More common location is base of skull or sacrococcygeal region
- Circumscribed, unencapsulated, with mucoid gray-white cut surface
- Nests and cords of physaliphorous cells (polygonal with multiple small cytoplasmic vacuoles) with hyperchromatic nuclei, prominent nucleoli), frequent mitotic activity, in myxochondroid matrix (Hum Pathol 1995;26:1354)
Abundant, bubbly vacuolated cytoplasm is CK+ (inset)
Electron microscopy description
- Keratin, EMA, S100, CD57/Leu7
End of Mediastinum > Other malignancies > Chordoma
- Intercellular junctions, intermediate filaments, rough endoplasmic reticulum complexed to mitochondria
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