Other malignancies

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 21 June 2018, last major update December 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Chordoma mediastinum

Cite this page: Gulwani, H. Chordoma. website. Accessed July 19th, 2018.
Definition / general
  • May present as paramedian posterior mediastinal mass in adults or children
  • More common location is base of skull or sacrococcygeal region
Gross description
  • Circumscribed, unencapsulated, with mucoid gray-white cut surface
Microscopic (histologic) description
  • Nests and cords of physaliphorous cells (polygonal with multiple small cytoplasmic vacuoles) with hyperchromatic nuclei, prominent nucleoli), frequent mitotic activity, in myxochondroid matrix (Hum Pathol 1995;26:1354)
Microscopic (histologic) images

Images hosted on other servers:

Abundant, bubbly
cytoplasm is
CK+ (inset)

Positive stains
Electron microscopy description
  • Intercellular junctions, intermediate filaments, rough endoplasmic reticulum complexed to mitochondria