Mediastinum - Seminoma

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Mediastinum

Cystic lesions

Seminoma - cystic

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 24 February 2013, last major update December 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Cysts are due to degenerative changes, may be prominent (Am J Surg Pathol 1995;19:1047)
● Usually in anterosuperior mediastinum

Clinical features
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● Associated with Klinefelter’s syndrome (XXY), hematologic abnormalities

Case reports
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● Prominent cystic change and high CA19-9 level of cystic fluid (Ann Thorac Surg 2009;88:1693)

Gross description
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● Variable cystic contents, unilocular or multilocular

Micro description
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● Seminoma cells present in cyst wall, but may not be numerous
● Have glycogen rich cytoplasm with marked retraction, coarse chromatin with prominent nucleoli, variable mitotic figures
● Subdivided by fine fibrous trabeculae
● Associated with germinal centers, giant cells
● No cholesterol granulomas (may have other granulomas), no cartilage, no smooth muscle

Positive stains
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● PAS, PLAP

End of Mediastinum > Cystic lesions > Seminoma - cystic

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