Mediastinum
Nonneoplastic
Diffuse thymic fibrosis


Topic Completed: 1 December 2012

Minor changes: 20 November 2019

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PubMed Search: Diffuse thymic fibrosis

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. Diffuse thymic fibrosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumdiffusethymicfibrosis.html. Accessed September 19th, 2020.
Definition / general
  • Uncommon disorder with no / limited symptoms; may have dyspnea, cough or hemoptysis
  • Area of diffuse fibrosis varies from 3.5 - 17 cm, confined to anterior mediastinum
  • Unknown etiology; altered immunity or infection may play a role
  • Males and females, mean age 48 years
Microscopic (histologic) description
  • Diffuse fibrosis with variable collagen deposition, lymphoplasmacytic infiltrates and involution / atrophy of thymus
  • May show IgG4+ plasma cells and focal obliterative phlebitis (Am J Surg Pathol 2010;34:211)
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