Diffuse thymic fibrosis

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 14 June 2018, last major update December 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Diffuse thymic fibrosis

Cite this page: Gulwani, H. Diffuse thymic fibrosis. website. Accessed July 21st, 2018.
Definition / general
  • Uncommon disorder with no / limited symptoms; may have dyspnea, cough or hemoptysis
  • Area of diffuse fibrosis varies from 3.5 - 17 cm, confined to anterior mediastinum
  • Unknown etiology; altered immunity or infection may play a role
  • Males and females, mean age 48 years
Microscopic (histologic) description
  • Diffuse fibrosis with variable collagen deposition, lymphoplasmacytic infiltrates and involution / atrophy of thymus
  • May show IgG4+ plasma cells and focal obliterative phlebitis (Am J Surg Pathol 2010;34:211)