Other benign / low grade tumors

Topic Completed: 1 December 2012

Revised: 13 February 2019

Copyright: 2003-2018,, Inc.

PubMed Search: Ganglioneuroma[TI] mediastinum

Hanni Gulwani, M.B.B.S.
Page views in 2018: 915
Page views in 2019 to date: 1,292
Cite this page: Gulwani H. Ganglioneuroma. website. Accessed September 23rd, 2019.
Definition / general
  • Benign neural tumor; more common than neuroblastoma or ganglioneuroblastoma
  • Usually children; also age 20 - 39 years
Clinical features
  • No symptoms in most cases
  • Rarely watery diarrhea from vasoactive intestinal peptide (VIP) synthesis or symptoms of spinal nerve root compression
  • Clinical diagnosis is aided by integrating age, clinical findings, location, imaging (AJR Am J Roentgenol 2011;197:W643)
Case reports
  • Excision is curative
Gross description
  • Encapsulated, glistening tumor
  • May have intradural growth and dumbbell shape
  • Soft, yellow-gray cut surface, may have cystic and fatty areas, usually no necrosis
Gross images

Images hosted on other servers:

21 cm ganglioneuroma

Well circumscribed
tumor with whorled

Microscopic (histologic) description
  • Spindle cell (Schwannian) proliferation similar to neurofibroma but with well formed ganglion cells, often in clusters and multinucleated
  • Focal lymphocytes present
Microscopic (histologic) images

Images hosted on other servers:

Ganglion cells admixed with Schwann cells

Ganglions and Schwann cells

Spindled Schwann cells and scattered ganglion cells

Positive stains
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