Mediastinum
Other benign / low grade tumors
Ganglioneuroma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 18 June 2018, last major update December 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Ganglioneuroma[TI] mediastinum

Cite this page: Gulwani, H. Ganglioneuroma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumganglioneuroma.html. Accessed August 17th, 2018.
Definition / general
  • Benign neural tumor; more common than neuroblastoma or ganglioneuroblastoma
Epidemiology
  • Usually children; also age 20 - 39 years
Clinical features
  • No symptoms in most cases
  • Rarely watery diarrhea from vasoactive intestinal peptide (VIP) synthesis or symptoms of spinal nerve root compression
  • Clinical diagnosis is aided by integrating age, clinical findings, location, imaging (AJR Am J Roentgenol 2011;197:W643)
Case reports
Treatment
  • Excision is curative
Gross description
  • Encapsulated, glistening tumor
  • May have intradural growth and dumbbell shape
  • Soft, yellow-gray cut surface, may have cystic and fatty areas, usually no necrosis
Gross images

Images hosted on other servers:

21 cm ganglioneuroma

Well circumscribed
tumor with whorled
appearance

Microscopic (histologic) description
  • Spindle cell (Schwannian) proliferation similar to neurofibroma but with well formed ganglion cells, often in clusters and multinucleated
  • Focal lymphocytes present
Microscopic (histologic) images

Images hosted on other servers:

Ganglion cells admixed with Schwann cells

Ganglions and Schwann cells

Spindled Schwann cells and scattered ganglion cells

Positive stains