Mediastinum
Hematological neoplasms / lesions
Granulocytic sarcoma




Topic Completed: 1 December 2012

Revised: 14 February 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Granulocytic sarcoma mediastinum

Page views in 2018: 121
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Cite this page: Gulwani H. Granulocytic sarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumgranulocyticsarcoma.html. Accessed May 22nd, 2019.
Terminology
  • Also called extramedullary myelogenous leukemia, chloroma
Epidemiology
  • Usually 35 years old or younger or 65 years+
Clinical features
  • May be associated with myeloproliferative disease, acute myelogenous leukemia
Diagnosis
  • Touch preps are helpful for diagnosis - show Auer rods with Romanowsky stain
Prognostic factors
  • Poor prognosis; usually evolves to acute myelogenous leukemia
Case reports
Gross description
  • Bulky anterior intrathoracic mass, green on cut section (hence "chloroma"), often centered in thymus
  • Fleshy, multilobated, poorly delineated, unencapsulated with hemorrhage and necrosis
  • May directly extend to thoracic structures
Microscopic (histologic) description
  • Sheets of large, monomorphic, polyhedral cells with irregular nuclear contours, vesicular chromatin, variable nucleoli
  • Mature and immature eosinophils
Electron microscopy description
  • Primary granules often present
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