Mediastinum
Other malignancies
Liposarcoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 21 June 2018, last major update December 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Liposarcoma[TI] mediastinum

Cite this page: Gulwani, H. Liposarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumliposarcoma.html. Accessed July 17th, 2018.
Diagrams / tables

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Clinicopathologic features of childhood cases

Clinical features
  • Rare in mediastinum; age range of 3 - 72 years
  • More common in anterior / posterior than superior mediastinum
  • Well circumscribed multinodular masses, 2 - 61 cm
  • Most common subtypes: well differentiated, dedifferentiated, pleomorphic (myxoid uncommon, Am J Surg Pathol 2007;31:1868)
  • Mediastinum shows a preponderance of uncommon subtypes and unusual morphologic variants; correct classification has important implications, with most patients with well differentiated / dedifferentiated liposarcoma having a protracted clinical course, in contrast to the more rapid disease progression seen in patients with myxoid and pleomorphic liposarcoma (Am J Surg Pathol 2012;36:1395)
  • Associated with liposarcoma of thigh or retroperitoneum as a multicentric tumor
  • Lipoleiomyosaroma: well differentiated liposarcoma with leiomyosarcomatous differentiation (Am J Surg Pathol 2002;26:742)
Case reports
Microscopic (histologic) images

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Various patterns