Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 23 February 2013, last major update December 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Also called cystic hygroma
● Benign proliferation of lymphatic channels
● Common; in anterior, middle or posterior mediastinum or soft tissue of neck
● Large lesions may compress lungs, heart, nerves, but most lesions are asymptomatic and found on Xray
● Usually in children, often with cervical component, rarely in adults (Ann Thorac Cardiovasc Surg 2001;7:103)
● 52 year old woman with mediastinal cystic lymphangioma (Jpn J Thorac Cardiovasc Surg 2004;52:567)
● Variegated appearance, appears to infiltrate mediastinal soft tissue
● Gray-white masses, edematous appearing, variable sized cystic cavities, serous type fluid, smooth inner lining
● Large, irregular vascular spaces lined by flattened, bland epithelial cells with fibroblastic or collagenous stroma
● Variable lymphocytic infiltrates; no specialized epithelium, no cholesterol granulomas
Lymphatic channels lined by attenuated endothelial cells
End of Mediastinum > Cystic lesions > Lymphangioma
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