Mediastinum
Hematological neoplasms / lesions
Lymphoblastic lymphoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 20 June 2018, last major update December 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Lymphoblastic lymphoma mediastinum

Cite this page: Gulwani, H. Lymphoblastic lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumlymphoblasticlymphoma.html. Accessed July 19th, 2018.
Definition / general
  • Typically presents with acute respiratory distress in teenager; systemic dissemination common
  • Usually T cell
Epidemiology
  • Usually teens / young adults
  • Also ages 60 - 79 years
  • Males more common than females
Case reports
  • 47 year old man with lymphoblastic lymphoma expressing natural killer cell phenotype with involvement of the mediastinum and nasal cavity (Am J Surg Pathol 1997;21:242)
Treatment
  • 5 year survival is 50% with multiagent chemotherapy
Gross description
  • Solid, soft, nonencapsulated, often extensive necrosis
Microscopic (histologic) description
  • Diffuse growth or pseudonodular pattern
  • Lymphocytes have even chromatin, inconspicuous nucleoli, increased nuclear/cytoplasmic ratio but with nuclear grooves, frequent mitotic figures, extension into adipose tissue, vascular invasion
  • Residual Hassall corpuscles may be present
Microscopic (histologic) images

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Precursor T cell type

Diffuse infiltrate of blasts replaces lymph node structure

Ill defined pale cytoplasm, fine nuclear chromatin

Positive stains
Negative stains
Differential diagnosis