Topic Completed: 1 December 2012

Minor changes: 6 February 2020

Copyright: 2003-2019,, Inc.

PubMed Search: Melanoma mediastinum

Hanni Gulwani, M.B.B.S.
Page views in 2019: 164
Page views in 2020 to date: 95
Cite this page: Gulwani H. Melanoma. website. Accessed May 30th, 2020.
Definition / general
  • Rarely occurs as mediastinal tumor with no known primary lesion
Prognostic factors
  • Very poor prognosis
Case reports
Gross images

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Internal fibrous bands and necrosis

Microscopic (histologic) description
  • Pleomorphic polygonal cells, often with delicate intracellular pigment and intranuclear pseudoinclusions of cytoplasm, prominent eosinophilic nucleoli, brisk mitotic activity
  • Variable geographic necrosis, no nuclear blebs
Microscopic (histologic) images

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Melanoma and adjacent thymus


Invasive melanoma in teratoma

Epithelioid and spindle cells

(D) Melanocytes with pleomorphic nuclei

Positive stains
Electron microscopy description
  • Premelanosomes, no branching surface microvilli
Electron microscopy images

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