Other malignancies

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 22 June 2018, last major update December 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Melanoma mediastinum

Cite this page: Gulwani, H. Melanoma. website. Accessed July 19th, 2018.
Definition / general
  • Rarely occurs as mediastinal tumor with no known primary lesion
Prognostic factors
  • Very poor prognosis
Case reports
Gross images

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Internal fibrous bands and necrosis

Microscopic (histologic) description
  • Pleomorphic polygonal cells, often with delicate intracellular pigment and intranuclear pseudoinclusions of cytoplasm, prominent eosinophilic nucleoli, brisk mitotic activity
  • Variable geographic necrosis, no nuclear blebs
Microscopic (histologic) images

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Melanoma and adjacent thymus


Invasive melanoma in teratoma

Epithelioid and spindle cells

(D) Melanocytes with pleomorphic nuclei

Positive stains
Electron microscopy description
  • Premelanosomes, no branching surface microvilli
Electron microscopy images

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