Mediastinum
Other malignancies
Melanoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 22 June 2018, last major update December 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Melanoma mediastinum

Cite this page: Gulwani, H. Melanoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinummelanoma.html. Accessed July 19th, 2018.
Definition / general
  • Rarely occurs as mediastinal tumor with no known primary lesion
Prognostic factors
  • Very poor prognosis
Case reports
Gross images

Images hosted on other servers:

Internal fibrous bands and necrosis

Microscopic (histologic) description
  • Pleomorphic polygonal cells, often with delicate intracellular pigment and intranuclear pseudoinclusions of cytoplasm, prominent eosinophilic nucleoli, brisk mitotic activity
  • Variable geographic necrosis, no nuclear blebs
Microscopic (histologic) images

Images hosted on other servers:

Melanoma and adjacent thymus

HMB45+

Invasive melanoma in teratoma

Epithelioid and spindle cells

(D) Melanocytes with pleomorphic nuclei

Positive stains
Electron microscopy description
  • Premelanosomes, no branching surface microvilli
Electron microscopy images

Images hosted on other servers:

Melanosomes