Mediastinum
Other malignancies
Mesothelioma




Topic Completed: 1 December 2012

Revised: 8 April 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Mesothelioma mediastinum
Page views in 2018: 454
Page views in 2019 to date: 344
Cite this page: Gulwani H. Mesothelioma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinummesothelioma.html. Accessed May 22nd, 2019.
Epidemiology
  • Usually men age 50+ years
  • 50% have history of high levels of aerosolized asbestos exposure
Sites
  • May originate in hilar reflections of pleura, although clear cut connection to serosal surface may not be present
  • Often with pleural or pericardial effusion
Prognostic factors
  • Very poor prognosis
Case reports
Microscopic (histologic) description
  • Biphasic or papillotubular pattern
  • Also sheets or nests of malignant polygonal cells with pleomorphism, prominent nucleoli and mitotic activity
  • Variable geographic necrosis, no nuclear blebs
Positive stains
Negative stains
Electron microscopy description
  • Long, branching, cellular microvilli with length/diameter ratio of 10 - 15:1
  • Cytoplasmic tonofibrils, elongated intercellular junctional complexes, no premelanosomes
Differential diagnosis
Sarcomatoid mesothelioma
Definition / general
  • Similar to classic mesothelioma except for presence of spindled and pleomorphic tumor cells

Differential diagnosis
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