Mediastinum
Other malignancies
Mesothelioma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 22 June 2018, last major update December 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Mesothelioma mediastinum

Cite this page: Gulwani, H. Mesothelioma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinummesothelioma.html. Accessed July 19th, 2018.
Epidemiology
  • Usually men age 50+ years
  • 50% have history of high levels of aerosolized asbestos exposure
Sites
  • May originate in hilar reflections of pleura, although clear cut connection to serosal surface may not be present
  • Often with pleural or pericardial effusion
Prognostic factors
  • Very poor prognosis
Case reports
Microscopic (histologic) description
  • Biphasic or papillotubular pattern
  • Also sheets or nests of malignant polygonal cells with pleomorphism, prominent nucleoli and mitotic activity
  • Variable geographic necrosis, no nuclear blebs
Positive stains
Negative stains
Electron microscopy description
  • Long, branching, cellular microvilli with length/diameter ratio of 10 - 15:1
  • Cytoplasmic tonofibrils, elongated intercellular junctional complexes, no premelanosomes
Differential diagnosis
Sarcomatoid mesothelioma
Definition / general
  • Similar to classic mesothelioma except for presence of spindled and pleomorphic tumor cells

Differential diagnosis