Mediastinum
Other malignancies
Neuroblastoma




Topic Completed: 1 December 2012

Revised: 14 February 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Neuroblastoma[TI] mediastinum

Page views in 2018: 394
Page views in 2019 to date: 189
Cite this page: Gulwani H. Neuroblastoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumneuroblastoma.html. Accessed March 22nd, 2019.
Definition / general
  • Usually primary tumors of posterior mediastinum associated with paraspinal nerve roots; rarely represents metastases to mediastinum
  • Symptoms due to compression of nerve roots or esophagus
  • May have opsoclonus myoclonus (dancing feet and eyes) due to paraneoplastic syndrome
Clinical features
  • Young children, usually < 1 year
  • Tumors of thymus and anterior mediastinum are associated with syndrome of inappropriate antidiuretic hormone
  • May relapse in central nervous system
Laboratory
  • Elevated HMA and VMA
  • Hyponatremia
Case reports
Gross description
  • Partially encapsulated, infiltrative, pink-gray fleshy cut surface, hemorrhage, necrosis, calcification
Microscopic (histologic) description
  • Small round blue cell tumor with sheets of monomorphic cells with scant eosinophilic cytoplasm, uniform chromatin, minimal nucleoli
  • Often brisk mitotic activity
  • Necrosis, dystrophic calcification, arborizing vasculature
  • Variable fibrillary eosinophilic intercellular matrix
  • Variable ganglion cells
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Negative stains
Electron microscopy description
  • Complex, long, interdigitating cytoplasmic processes with microtubules
  • May have synaptic vesicles and scant neurosecretory granules
  • No / minimal basal lamina, no / minimal intermediate filaments
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