Mediastinum
Soft tissue tumors
Neurofibroma


Topic Completed: 1 December 2012

Minor changes: 5 December 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Neurofibroma mediastinum

Hanni Gulwani, M.B.B.S.
Page views in 2019: 721
Page views in 2020 to date: 455
Cite this page: Gulwani H. Neurofibroma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumneurofibroma.html. Accessed July 7th, 2020.
Definition / general
  • Usually in posterior mediastinum, asymptomatic
  • May be multiple
  • Plexiform tumors are specific for neurofibromatosis
  • Benign
Epidemiology
  • Young adults
Treatment
Gross description
  • Often encapsulated in mediastinum (not at other sites)
  • Usually centered on or grow within a large spinal nerve root
  • May have intradural and extradural components and protrude through neural foramina of vertebral column
  • Plexiform tumors resemble a neural plexus
  • Degenerative changes are common (fat, hemorrhage, cysts)
Gross images

Images hosted on other servers:

Well circumscribed
myxomatous tumor
surrounded by thin
pseudocapsule

Microscopic (histologic) description
  • Uniform growth pattern of bland spindle cells in fascicles, storiform arrays or tactoids (elongated particles that appears as spindle shaped bodies under polarizing microscope)
  • Myxoid stroma, frequent mast cells, no distinct biphasic pattern
  • No thick walled blood vessels
Microscopic (histologic) images

Images hosted on other servers:

Fascicular proliferation of spindle tumor cells

Electron microscopy description
  • Fibroblast-like tumor cells with abundant rough endoplasmic reticulum, rudimentary cytoplasmic processes, sparse pericellular basal lamina
  • May lack evidence of Schwannian differentiation
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