Hematological neoplasms / lesions

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 20 June 2018, last major update December 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Plasmacytoma mediastinum

Cite this page: Gulwani, H. Plasmacytoma. website. Accessed July 19th, 2018.
  • Elderly, often with multiple myeloma or paraproteinemia
Case reports
Microscopic (histologic) description
  • Sheets of polygonal cells with round, eccentric nuclei, coarsely stippled chromatin (clockface nuclei), homogenous amphophilic cytoplasm
  • Also binucleated forms, perinuclear clearing (perinuclear hofs), discohesive cells at periphery
Microscopic (histologic) images

Images hosted on other servers:

CD138+ plasma cells

Plasma cells show excess lambda chain expression

Positive stains
Electron microscopy description
  • Abundant rough endoplasmic reticulum, no intercellular junctional complexes, no neurosecretory granules