Hematological neoplasms / lesions

Topic Completed: 1 December 2012

Revised: 14 February 2019

Copyright: 2003-2018,, Inc.

PubMed Search: Plasmacytoma mediastinum

Hanni Gulwani, M.B.B.S.
Page views in 2018: 42
Page views in 2019 to date: 90
Cite this page: Gulwani H. Plasmacytoma. website. Accessed September 16th, 2019.
  • Elderly, often with multiple myeloma or paraproteinemia
Case reports
Microscopic (histologic) description
  • Sheets of polygonal cells with round, eccentric nuclei, coarsely stippled chromatin (clockface nuclei), homogenous amphophilic cytoplasm
  • Also binucleated forms, perinuclear clearing (perinuclear hofs), discohesive cells at periphery
Microscopic (histologic) images

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CD138+ plasma cells

Plasma cells show excess lambda chain expression

Positive stains
Electron microscopy description
  • Abundant rough endoplasmic reticulum, no intercellular junctional complexes, no neurosecretory granules
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