Mediastinum
Other malignancies
Reticulum cell tumors

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 22 June 2018, last major update December 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Reticulum cell tumors mediastinum

See also: Follicular dendritic cell tumor
Cite this page: Gulwani, H. Reticulum cell tumors. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumreticulum.html. Accessed July 17th, 2018.
Interstitial reticulum cell tumors
Definition / general
  • Reticulum cells are keratin+, present in normal lymph nodes, subset of fibroblastic reticulum cells
  • Tumors are rare, may have bizarre giant cell and multinucleated features in HIV associated lymphadenopathy

Case reports
Microscopic (histologic) description
  • Noncohesive, ill defined fascicles of spindle cells with long, slender cytoplasmic processes, in a background of lymphocytes and plasma cells
  • Mild nuclear atypia
  • Variable mitotic activity
  • Usually no tumor necrosis

Positive stains
Negative stains
Electron microscopy description
  • Long interdigitating microvillous-like cell processes, some desmosomes between cells

Differential diagnosis
Interdigitating dendritic cell tumor
Positive stains
Negative stains
Electron microscopy description
  • Interdigitating cytoplasmic processes