Mediastinum
Other malignancies
Reticulum cell tumors



Topic Completed: 1 December 2012

Revised: 14 February 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Reticulum cell tumors mediastinum

See also: Follicular dendritic cell tumor

Hanni Gulwani, M.B.B.S.
Page views in 2018: 99
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Cite this page: Gulwani H. Reticulum cell tumors. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumreticulum.html. Accessed November 13th, 2019.
Interstitial reticulum cell tumors
Definition / general
  • Reticulum cells are keratin+, present in normal lymph nodes, subset of fibroblastic reticulum cells
  • Tumors are rare, may have bizarre giant cell and multinucleated features in HIV associated lymphadenopathy

Case reports
Microscopic (histologic) description
  • Noncohesive, ill defined fascicles of spindle cells with long, slender cytoplasmic processes, in a background of lymphocytes and plasma cells
  • Mild nuclear atypia
  • Variable mitotic activity
  • Usually no tumor necrosis

Positive stains
Negative stains
Electron microscopy description
  • Long interdigitating microvillous-like cell processes, some desmosomes between cells

Differential diagnosis
Interdigitating dendritic cell tumor
Positive stains
Negative stains
Electron microscopy description
  • Interdigitating cytoplasmic processes
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