Mediastinum
Other malignancies
Rhabdomyosarcoma

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 22 June 2018, last major update December 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Rhabdomyosarcoma mediastinum

Cite this page: Gulwani, H. Rhabdomyosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumrms.html. Accessed July 19th, 2018.
Definition / general
  • Children and teens with mass related symptoms but no paraneoplastic syndromes
  • Pure primary rhabdomyosarcomas of anterior mediastinum are highly aggressive (Hum Pathol 1994;25:349)
Case reports
Gross description
  • Poorly demarcated, bulky tumor of soft tissue, gray-white fleshy cut surface, hemorrhage and necrosis common
Microscopic (histologic) description
  • Small round blue cell tumor
  • Largely monomorphic but also with nuclear and cellular pleomorphism, scattered large multinuclear cells, deeply eosinophilic cytoplasm, eccentric nuclei, myxoid stromal change, alveolar growth, clear cell change
Microscopic (histologic) images

Images hosted on other servers:

Geographic necrosis

Embryonal rhabdomyosarcoma

Anaplastic nuclei

Various images

Positive stains

Positive stains
Negative stains
Electron microscopy description
  • Tight aggregates of cytoplasmic intermediate filaments, sometimes associated with thick filaments and organized as sarcomeres with Z bands
  • Glycogen, short segments of pericellular basal lamina
  • No intercellular junctions, no cytoplasmic processes, no microtubules, no synaptic vesicles, no dense core granules
Differential diagnosis