Soft tissue lesions

Topic Completed: 1 December 2012

Revised: 20 November 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Rhabdomyosarcoma mediastinum

Hanni Gulwani, M.B.B.S.
Page views in 2019: 201
Page views in 2020 to date: 27
Cite this page: Gulwani H. Rhabdomyosarcoma. website. Accessed January 26th, 2020.
Definition / general
  • Children and teens with mass related symptoms but no paraneoplastic syndromes
  • Pure primary rhabdomyosarcomas of anterior mediastinum are highly aggressive (Hum Pathol 1994;25:349)
Case reports
Gross description
  • Poorly demarcated, bulky tumor of soft tissue, gray-white fleshy cut surface, hemorrhage and necrosis common
Microscopic (histologic) description
  • Small round blue cell tumor
  • Largely monomorphic but also with nuclear and cellular pleomorphism, scattered large multinuclear cells, deeply eosinophilic cytoplasm, eccentric nuclei, myxoid stromal change, alveolar growth, clear cell change
Microscopic (histologic) images

Images hosted on other servers:

Geographic necrosis

Embryonal rhabdomyosarcoma

Anaplastic nuclei

Various images

Positive stains

Positive stains
Negative stains
Electron microscopy description
  • Tight aggregates of cytoplasmic intermediate filaments, sometimes associated with thick filaments and organized as sarcomeres with Z bands
  • Glycogen, short segments of pericellular basal lamina
  • No intercellular junctions, no cytoplasmic processes, no microtubules, no synaptic vesicles, no dense core granules
Differential diagnosis
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