Soft tissue lesions

Topic Completed: 1 December 2012

Minor changes: 7 February 2020

Copyright: 2003-2019,, Inc.

PubMed Search: Rhabdomyosarcoma mediastinum

Hanni Gulwani, M.B.B.S.
Page views in 2019: 201
Page views in 2020 to date: 147
Cite this page: Gulwani H. Rhabdomyosarcoma. website. Accessed June 1st, 2020.
Definition / general
  • Children and teens with mass related symptoms but no paraneoplastic syndromes
  • Pure primary rhabdomyosarcomas of anterior mediastinum are highly aggressive (Hum Pathol 1994;25:349)
Case reports
Gross description
  • Poorly demarcated, bulky tumor of soft tissue, gray-white fleshy cut surface, hemorrhage and necrosis common
Microscopic (histologic) description
  • Small round blue cell tumor
  • Largely monomorphic but also with nuclear and cellular pleomorphism, scattered large multinuclear cells, deeply eosinophilic cytoplasm, eccentric nuclei, myxoid stromal change, alveolar growth, clear cell change
Microscopic (histologic) images

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Various images

Positive stains

Positive stains
Negative stains
Electron microscopy description
  • Tight aggregates of cytoplasmic intermediate filaments, sometimes associated with thick filaments and organized as sarcomeres with Z bands
  • Glycogen, short segments of pericellular basal lamina
  • No intercellular junctions, no cytoplasmic processes, no microtubules, no synaptic vesicles, no dense core granules
Differential diagnosis
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