Mediastinum
Thymic carcinoma
Squamous cell thymic carcinoma, keratinizing

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 19 June 2018, last major update December 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Squamous cell thymic carcinoma keratinizing

Cite this page: Gulwani, H. Squamous cell thymic carcinoma, keratinizing. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumscckeratin.html. Accessed October 17th, 2018.
Clinical features
  • Associated with hypercalcemia, elevated PTH levels
Prognostic factors
  • Good prognosis with few fatalities if well differentiated
Microscopic (histologic) description
  • Similar to tumor in skin, lung, other sites
  • Lobular growth with fibrous bands
  • Nests and cords of large polyhedral cells with intercellular bridges
  • Vesicular or hyperchromatic nuclei, prominent nucleoli, eosinophilic or glassy cytoplasm, keratin pearls
  • Also angiolymphatic invasion, necrosis
  • Rarely coexists with thymoma
Microscopic (histologic) images

Images hosted on other servers:

Left: well differentiated
squamous cell carcinoma
of the thymus showing
focus of keratinization

Differential diagnosis