• Good prognosis with few fatalities if well differentiated

• Associated with hypercalcemia, elevated PTH levels

• Similar to tumor in skin, lung, other sites
• Lobular growth with fibrous bands
• Nests and cords of large polyhedral cells with intercellular bridges
• Vesicular or hyperchromatic nuclei, prominent nucleoli, eosinophilic or glassy cytoplasm, keratin pearls
• Also angiolymphatic invasion, necrosis
• Rarely coexists with thymoma

Left: well-differentiated squamous cell carcinoma of the thymus showing focus of keratinization

• Metastatic carcinoma

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