Mediastinum
Thymic carcinoma
Squamous cell thymic carcinoma, keratinizing




Topic Completed: 1 December 2012

Revised: 14 February 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Squamous cell thymic carcinoma keratinizing

Page views in 2018: 305
Page views in 2019 to date: 149
Cite this page: Gulwani H. Squamous cell thymic carcinoma, keratinizing. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumscckeratin.html. Accessed March 22nd, 2019.
Clinical features
  • Associated with hypercalcemia, elevated PTH levels
Prognostic factors
  • Good prognosis with few fatalities if well differentiated
Microscopic (histologic) description
  • Similar to tumor in skin, lung, other sites
  • Lobular growth with fibrous bands
  • Nests and cords of large polyhedral cells with intercellular bridges
  • Vesicular or hyperchromatic nuclei, prominent nucleoli, eosinophilic or glassy cytoplasm, keratin pearls
  • Also angiolymphatic invasion, necrosis
  • Rarely coexists with thymoma
Microscopic (histologic) images

Images hosted on other servers:

Left: well differentiated
squamous cell carcinoma
of the thymus showing
focus of keratinization

Differential diagnosis
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