Home   Chapter Home   Jobs   Conferences   Fellowships   Books




Thymic dysplasia

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 23 February 2013, last major update December 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.


● Congenital thymic alteration due to developmental arrest
● Lack of differentiation of thymic epithelium, responsible for absence of Hassal's corpuscles, is main feature (Histopathology 1992;21:499)

Clinical features

● Associated with severe combined immunodeficiency syndrome, ataxia-telangiectasia, chromosomal instability syndromes, Nezelof syndrome (Arch Pathol Lab Med 1987;111:1118)
● Incomplete form of DiGeorge syndrome is congenital anomaly with a constellation of findings that includes thymic hypoplasia (J Cutan Pathol 2008;35:380); complete form has absent thymus

Gross description

● Small thymus (< 5g)

Micro description

● Tubules and rosettes of primitive appearing epithelium without segregation into cortical and medullary regions
● No Hassallís corpuscles, no/rare lymphocytes

Differential diagnosis

Acute thymic involution

End of Mediastinum > Thymus > Thymic dysplasia

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).