Thymic follicular hyperplasia
Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 23 February 2013, last major update December 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Defined as substantial numbers of lymphoid follicles in thymus of adults
● Thymus usually has normal size / weight
● Present in 65% with myasthenia gravis
● Also associated with hyperthyroidism, Addison’s disease, SLE, early HIV, multilocular cysts, other immune-related diseases
● Often differerent clinical history than true thymic hyperplasia (Pathologica 2009;101:175)
● Follicles with germinal centers, medullary epithelial cells may be disordered or hypertrophied
|Lymphoid follicles in the thymus in a patient with myasthenia gravis|
● Normal lymphoid follicles of infants / children (few present)
End of Mediastinum > Thymus > Thymic follicular hyperplasia
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