Thymic follicular hyperplasia

Topic Completed: 1 December 2012

Revised: 13 February 2019

Copyright: 2003-2018,, Inc.

PubMed Search: Thymic follicular hyperplasia

Hanni Gulwani, M.B.B.S.
Page views in 2018: 2,599
Page views in 2019 to date: 2,120
Cite this page: Gulwani H. Thymic follicular hyperplasia. website. Accessed September 23rd, 2019.
Definition / general
  • Defined as substantial numbers of lymphoid follicles in thymus of adults
  • Thymus usually has normal size / weight
Clinical features
  • Present in 65% with myasthenia gravis
  • Also associated with hyperthyroidism, Addison disease, SLE, early HIV, multilocular cysts, other immune related diseases
  • Often different clinical history than true thymic hyperplasia (Pathologica 2009;101:175)
Microscopic (histologic) description
  • Follicles with germinal centers, medullary epithelial cells may be disordered or hypertrophied
Microscopic (histologic) images

Images hosted on other servers:

Lymphoid follicles composed of B cells

Lymphoid follicles in the thymus in a patient with myasthenia gravis

Differential diagnosis
  • Normal lymphoid follicles of infants / children (few present)
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