Thymoma and related entities
Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 27 February 2013, last major update December 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Increased thymic volume, due to lobules of mature adipose tissue mixed with unremarkable thymic tissue
● May be neoplasm of thymic fat (Ann Diagn Pathol 2009;13:185)
● Usually young to middle-aged adults, found incidentally
● 10% associated with thymoma-like paraneoplastic symptoms
● 26 year old woman with possible origin from thymic true hyperplasia
(Int J Surg Pathol 2010;18:526)
● 36 year old woman with thymoma and thymic carcinoma arising in thymolipoma (Int J Surg Pathol 2009;17:55)
● 69 year old man with 570g mediastinal mass (Arch Pathol Lab Med 2004;128:e159)
● Encapsulated, up to 20 cm
● Resembles lipoma
● Thin fibrous capsule surrounding lobules of mature adipose tissue intimately associated with unremarkable thymic tissue containing cortex, medulla and Hassallís corpuscles
● May have thymic epithelial proliferation, myoid cells, zones of dense fibrosis
Various images, CK903
End of Mediastinum > Thymoma and related entities > Thymolipoma
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