Thymoma and related entities

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 20 November 2015, last major update December 2012

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Thymolipoma [title]
Definition / General
  • Increased thymic volume, due to lobules of mature adipose tissue mixed with unremarkable thymic tissue
  • Benign
  • May be neoplasm of thymic fat (Ann Diagn Pathol 2009;13:185)
  • Usually young to middle-aged adults, found incidentally
Clinical Features
  • 10% associated with thymoma-like paraneoplastic symptoms
Case Reports
Gross Description
  • Encapsulated, up to 20 cm
  • Resembles lipoma
Micro Description
  • Thin fibrous capsule surrounding lobules of mature adipose tissue intimately associated with unremarkable thymic tissue containing cortex, medulla and Hassall's corpuscles
  • May have thymic epithelial proliferation, myoid cells, zones of dense fibrosis
Micro Images
Images posted on PathOut server:
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Mature adipose tissue admixed with unremarkable thymic tissue
Courtesy of Snehal Sonawane, M.D.

Images posted on Other servers:
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Thymic elements within mature adipose tissue

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Various images, CK903