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Mediastinum

Thymoma and related entities

Thymolipoma

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 27 February 2013, last major update December 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Increased thymic volume, due to lobules of mature adipose tissue mixed with unremarkable thymic tissue
● Benign
● May be neoplasm of thymic fat (Ann Diagn Pathol 2009;13:185)

Epidemiology
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● Usually young to middle-aged adults, found incidentally

Clinical features
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● 10% associated with thymoma-like paraneoplastic symptoms

Case reports
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● 26 year old woman with possible origin from thymic true hyperplasia (Int J Surg Pathol 2010;18:526)
● 36 year old woman with thymoma and thymic carcinoma arising in thymolipoma (Int J Surg Pathol 2009;17:55)
● 69 year old man with 570g mediastinal mass (Arch Pathol Lab Med 2004;128:e159)

Gross description
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● Encapsulated, up to 20 cm
● Resembles lipoma

Micro description
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● Thin fibrous capsule surrounding lobules of mature adipose tissue intimately associated with unremarkable thymic tissue containing cortex, medulla and Hassall’s corpuscles
● May have thymic epithelial proliferation, myoid cells, zones of dense fibrosis

Micro images
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Various images, CK903

End of Mediastinum > Thymoma and related entities > Thymolipoma

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