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True thymic hyperplasia

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 23 February 2013, last major update December 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.


● Thymus larger than normal limits for age, based on tables
● Otherwise histologically unremarkable


● Often in infants or children, or in adults after cancer chemotherapy

Case reports

● 5 week old boy with severe thymic cyst bleeding (Ann Diagn Pathol 2007;11:358)
● 22 year old man with thymic hemorrhage (Pathol Res Pract 2010;206:331)
● 24 year old woman who was treated for T-cell lymphoma (J Clin Oncol 2004;22:953)
● 26 year old woman with thymolipoma, suggesting an origin from thymic true hyperplasia (Int J Surg Pathol 2010;18:526)
● 53 year old woman with unilocular thymic cyst (Ann Diagn Pathol 2006;10:32)

Micro images

Low power view

Histologically normal thymus

Normal thymus-Hassallís corpuscle

p63, XIAP


● p63+, XIAP- (Am J Clin Pathol 2009;131:689)

End of Mediastinum > Thymus > True thymic hyperplasia

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