Molecular markers
Melanoma mutations
ARID2

Author: Joshua Bradish, M.D. (see Authors page)
Editor: Gregory A. Hosler, M.D., Ph.D.

Revised: 12 June 2018, last major update September 2014

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: ARID2
Cite this page: Bradish, J. ARID2. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/molecularpathARID2.html. Accessed October 21st, 2018.
Definition / general
  • ARID2, AT rich interactive domain containing protein 2, functions as a tumor suppressor gene / protein
  • It is located on chromosome 12q
  • ARID2 is a subunit of a chromatin remodeling complex
  • It functions to facilitate ligand dependent transcriptional activity by nuclear receptors (Genes Dev 2005;19:1662, Oncotarget 2011;2:886)
Diagrams / tables

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ARID2 associations

Clinical features
  • ARID2 is associated with melanoma and hepatocellular carcinoma most commonly but has been described in many other tumors
  • No studies have described specific histological findings with ARID2 mutations
Microscopic (histologic) description
  • Detection of ARID2 mutations is not routinely performed in melanocytic proliferations
  • Inactivation mutations can be detected through whole exome sequencing and microarray
  • No mechanisms of resistance have been evaluated
Resistance therapies
  • No resistance therapies have been evaluated
Molecular / cytogenetics description
  • ARID2 mutations causing disease are loss of function mutations
  • Nonsense mutations are predicted to lack the Zn motifs required for DNA binding
  • There is some suggestion that UVB may cause some of these mutations leading to melanomagenesis (Cell 2012;150:251)