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Molecular Pathology
Microarray
Variations - Cellular microarray
Author: Rodney E. Shackelford, DO, Ph.D. (see Reviewers page)
Revised: 3 July 2010, last major update July 2010
Copyright: (c) 2008-2010, PathologyOutlines.com, Inc.
General
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● Cellular microarray uses living cells as a target and solid phase probes, which can consist of nucleic acids, antibodies, lipids, proteins, cytokines or any substance to which the cells being examined may bind
● Like other microarray assays, the target cells are hybridized to the chip, washed extensively, and the binding pattern is analyzed
● Cell count, cell type capture, cell response or changes in cell morphology/phenotype may be analyzed following different treatments applied to the washed chip (staining, morphologic evaluation, etc)
● An interesting variation is done with MHC class I or II spotted chips, which allow the analysis of the MHC binding activities of a cell population.
End of Molecular Pathology > Microarray > Variations > Cellular microarray
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