Table of ContentsDefinition / general
Cite this page: Shackelford, R.E. Cellular microarray. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/molecularpathmicroarraycellular.html. Accessed January 17th, 2019.
Definition / general
- Cellular microarray uses living cells as a target and solid phase probes, which can consist of nucleic acids, antibodies, lipids, proteins, cytokines or any substance to which the cells being examined may bind
- Like other microarray assays, the target cells are hybridized to the chip, washed extensively and the binding pattern is analyzed
- Cell count, cell type capture, cell response or changes in cell morphology / phenotype may be analyzed following different treatments applied to the washed chip (staining, morphologic evaluation, etc.)
- Interesting variation is done with MHC class I or II spotted chips, which allow the analysis of the MHC binding activities of a cell population