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Molecular Pathology

Microarray

Variations - Cellular microarray

 

Author: Rodney E. Shackelford, DO, Ph.D. (see Reviewers page)

Revised: 3 July 2010, last major update July 2010

Copyright: (c) 2008-2010, PathologyOutlines.com, Inc.

 

General

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Cellular microarray uses living cells as a target and solid phase probes, which can consist of nucleic acids, antibodies, lipids, proteins, cytokines or any substance to which the cells being examined may bind

Like other microarray assays, the target cells are hybridized to the chip, washed extensively, and the binding pattern is analyzed

Cell count, cell type capture, cell response or changes in cell morphology/phenotype may be analyzed following different treatments applied to the washed chip (staining, morphologic evaluation, etc)

An interesting variation is done with MHC class I or II spotted chips, which allow the analysis of the MHC binding activities of a cell population.

 

End of Molecular Pathology > Microarray > Variations > Cellular microarray

 

 

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