Chronic myeloid neoplasms
Myelodysplastic syndromes
5q- syndrome



Topic Completed: 1 August 2011

Revised: 31 December 2018, last major update August 2011

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: 5q- syndrome [title]


Nikhil Sangle, M.D.
Page views in 2018: 363
Page views in 2019 to date: 287
Cite this page: Sangle N. 5q- syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/myeloproliferative5qminus.html. Accessed July 22nd, 2019.
Definition / general
  • Subtype of refractory anemia with good prognosis
  • Stable clinical course but often transfusion dependent causing frequent hemochromatosis
  • Usually elderly women
  • 10% progress to AML
Laboratory
  • Moderate to severe macrocytic anemia, thrombocytosis in 50%
Treatment
Microscopic (histologic) description
  • Bone marrow biopsy: usually hypercellular or normocellular, erythroid hypoplasia, increased clusters of megakaryocytes with abundant cytoplasm but hypolobulated or nonlobated nuclei
  • Bone marrow smear: reduced erythroblasts, megakaryocyte hyperplasia with nuclear hypolobulation; either granulocyte or megakaryocyte dysplasia but not both, < 5% blasts in BM and < 1% blasts in PB, no Auer rods
Microscopic (histologic) images

Images hosted on PathOut server:

Peripheral blood:

Blast and numerous platelets (platelet count was 567K)


Bone marrow biopsy:

Increased megakaryocytes
with overall increased
PAS+ cytoplasm,
nuclear hypolobulation


Bone marrow smear:

Two small megakaryocytes
have granular cytoplasm and
nonlobulated nuclei,
otherwise classified as RAEB

Molecular / cytogenetics description
  • Interstitial deletions of 5q12 to 5q32
  • If additional cytogenetic abnormalities are present (except loss of Y chromosome), do NOT categorized as 5q- MDS
Molecular / cytogenetics images

Images hosted on other servers:

Karyotypes

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