Chronic myeloid neoplasms
Myeloid neoplasms associated with eosinophilia and abnormalities
Myeloid neoplasm associated with PDGFRB rearrangement




Topic Completed: 1 August 2011

Revised: 31 December 2018, last major update August 2011

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PubMed Search: Myeloid neoplasm "PDGFRB rearrangement"

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Cite this page: Sangle N. Myeloid neoplasm associated with PDGFRB rearrangement. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/myeloproliferativePDGFRB.html. Accessed May 20th, 2019.
Definition / general
  • Very rare
  • Also called chronic myelomonocytic leukemia with eosinophilia associated with t(5;12)
  • PDGFRB is at 5q31-33
Diagnosis
  • Bone marrow examination with tryptase stain, T cell clonal studies
  • Use of immunostains, cytogenetics and molecular studies to detect PDFGRB rearrangement and absence of BCR-ABL
Laboratory
  • Leukocytosis and eosinophilia
  • Variable monocytosis and neutrophilia
  • Anemia and thrombocytopenia
Treatment
Molecular / cytogenetics description
  • t(5;12)(q31-q33;p12) or a variant translocation or ETV6-PDGFRB fusion gene
  • ETV6, previously known as TEL (Acta Haematol 2002;107:113)
Molecular / cytogenetics description

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FISH assays indicate rearrangement of PDGFRB

Differential diagnosis
Additional references
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