Chronic Myeloid Neoplasms
Reviewer: Nikhil Sangle, M.D., University of Utah & ARUP Laboratories (see Reviewers page)
Revised: 25 July 2011, last major update July 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.
● May cause myelodysplastic changes in erythroblasts and neutrophils
● Patients present with pancytopenia and hypo/normocellular marrow with dysplastic elements
● Note: arsenic trioxide is also a treatment for myelodysplasia (Curr Hematol Rep 2005;4:59)
● 41 year old woman with GI and neurologic symptoms for 6 months plus pancytopenia (Am J Hematol 1991;36:291)
● Peripheral blood: erythrocytes show coarse basophilic stippling and karyorrhexis
(Am J Clin Pathol 1984;81:533)
● Bone marrow: erythroblasts show megaloblastic changes and karyorrhexis (Blood 1975;45:241)
Peripheral blood images:
Erythroid precursor with slightly lobulated megaloblastoid nucleus
Bone marrow smear:
Erythroid precursors have marked dysplastic changes including nuclear lobulation and karyorrhexis
● Megaloblastic features of high N/C ratio and nuclear-cytoplasmic dyssynchrony
End of Chronic Myeloid Neoplasms > Myelodysplastic syndromes > Arsenic toxicity
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