Chronic Myeloid Neoplasms
Myelodysplastic syndromes
Arsenic toxicity




Topic Completed: 1 July 2011

Revised: 31 December 2018, last major update July 2011

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PubMed Search: "Myelodysplastic syndromes" Arsenic toxicity

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Cite this page: Sangle N. Arsenic toxicity. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/myeloproliferativearsenic.html. Accessed May 23rd, 2019.
Definition / general
  • May cause myelodysplastic changes in erythroblasts and neutrophils
  • Patients present with pancytopenia and hypo / normocellular marrow with dysplastic elements
  • Note: arsenic trioxide is also a treatment for myelodysplasia (Curr Hematol Rep 2005;4:59)
Case reports
Microscopic (histologic) description
Microscopic (histologic) images

Images hosted on PathOut server:


Peripheral blood images:

Erythroid precursor
with slightly lobulated
megaloblastoid nucleus


Bone marrow smear:

Erythroid precursors have
marked dysplastic changes
including nuclear lobulation
and karyorrhexis

Electron microscopy description
  • Megaloblastic features of high N/C ratio and nuclear cytoplasmic dyssynchrony (Blood 1979;53:820)
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