Chronic Myeloid Neoplasms
Myelodysplastic syndromes
Arsenic toxicity

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 28 February 2017, last major update July 2011

Copyright: (c) 2002-2017,, Inc.

PubMed Search: "Myelodysplastic syndromes" Arsenic toxicity

Cite this page: Arsenic toxicity. website. Accessed June 19th, 2018.
Definition / general
  • May cause myelodysplastic changes in erythroblasts and neutrophils
  • Patients present with pancytopenia and hypo / normocellular marrow with dysplastic elements
  • Note: arsenic trioxide is also a treatment for myelodysplasia (Curr Hematol Rep 2005;4:59)
Case reports
Microscopic (histologic) description
Microscopic (histologic) images

Images hosted on PathOut server:

Peripheral blood images:

Erythroid precursor
with slightly lobulated
megaloblastoid nucleus

Bone marrow smear:

Erythroid precursors have
marked dysplastic changes
including nuclear lobulation
and karyorrhexis

Electron microscopy description
  • Megaloblastic features of high N/C ratio and nuclear cytoplasmic dyssynchrony (Blood 1979;53:820)