Home   Chapter Home   Jobs   Conferences   Fellowships   Books


Chronic Myeloid Neoplasms

Myelodysplastic syndromes

Arsenic toxicity

Reviewer: Nikhil Sangle, M.D., University of Utah & ARUP Laboratories (see Reviewers page)
Revised: 25 July 2011, last major update July 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.


● May cause myelodysplastic changes in erythroblasts and neutrophils
● Patients present with pancytopenia and hypo/normocellular marrow with dysplastic elements
● Note: arsenic trioxide is also a treatment for myelodysplasia (Curr Hematol Rep 2005;4:59)

Case reports

● 41 year old woman with GI and neurologic symptoms for 6 months plus pancytopenia (Am J Hematol 1991;36:291)

Micro description

Peripheral blood: erythrocytes show coarse basophilic stippling and karyorrhexis (Am J Clin Pathol 1984;81:533)
Bone marrow: erythroblasts show megaloblastic changes and karyorrhexis (Blood 1975;45:241)

Micro images

Peripheral blood images:

Erythroid precursor with slightly lobulated megaloblastoid nucleus

Bone marrow smear:

Erythroid precursors have marked dysplastic changes including nuclear lobulation and karyorrhexis

EM description

● Megaloblastic features of high N/C ratio and nuclear-cytoplasmic dyssynchrony (Blood 1979;53:820)

End of Chronic Myeloid Neoplasms > Myelodysplastic syndromes > Arsenic toxicity

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).