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Chronic Myeloid Neoplasms

MDS/MPN

Chronic myelomonocytic leukemia with eosinophilia


Reviewer: Nikhil Sangle, M.D. (see Reviewers page)
Revised: 10 August 2011, last major update August 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.

Clinical features
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● Rare (<2% of cases); <50 cases reported to date
● Associated with t(5;12)(q33;p13) - PDGFRbeta and TEL genes (Blood 1995;85:2848)
● Peripheral eosinophil count > 1500 per microliter; occasionally has only bone marrow eosinophilia
● Men, median age 55 years, range 18-68 years
● Usually fatal, often due to blast crisis with additional cytogenetic aberrations (Am J Clin Pathol 2006;125:49)

Case reports
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● 63 year old man with abnormal bone marrow eosinophils (Arch Pathol Lab Med 2003;127:1214)

Treatment
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● Imatinib may be useful (Blood 2002;100:1088)

Micro description
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Peripheral blood: marked leukocytosis with eosinophilia (80%), monocytosis (60%) and basophilia (40%)
Bone marrow: hypercellular

Micro images
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Various images

Cytogenetic images
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Karyotype

Additional references
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Acta Haematol 2002;107:113, Atlas of Genetics and Cytogenetics

End of Chronic Myeloid Neoplasms > MDS/MPN > Chronic myelomonocytic leukemia with eosinophilia


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