Chronic Myeloid Neoplasms
MDS / MPN - unclassifiable

Topic Completed: 1 August 2011

Revised: 31 December 2018, last major update August 2011

Copyright: (c) 2002-2017,, Inc.

PubMed Search: MDS/MPN unclassifiable

Nikhil Sangle, M.D.
Page views in 2018: 399
Page views in 2019 to date: 268
Cite this page: Sangle N. MDS / MPN - unclassifiable. website. Accessed September 23rd, 2019.
Definition / general
  • This is a provisional myelodysplasia / myeloproliferative disorder (Haematologica 2008;93:34, Blood 2006;108:2173), with JAK2 V617F mutation present in 48 - 67%
  • Diagnostic criteria: features of one of the myelodysplasia / myeloproliferative categories but no history of MDS/MPN, no history of growth factor or cytotoxic therapy, no BCR-ABL1 gene fusion, no rearrangement of PDGFRA, PDGFRB or FGFR1, no del(5q), no inv(3)(q21;q26) OR de novo disease with MPN and MDS features which cannot be assigned to any specific category of MDS/MPN
  • Includes refractory anemia with ringed sideroblasts (RARS) with dyserythropoiesis and marked thrombocytosis (RARS-T) with megakaryocytes similar to those in ET, PV or primary myelofibrosis
Case reports
Microscopic (histologic) images

Images hosted on other servers:

Peripheral blood:

Essential thrombocythemia with ringed sideroblasts; Fig 1: peripheral blood shows occasional giant platelets
Fig 2: hypercellular (70%) marrow
Fig 3: clusters of megakaryocytes with hyperlobulation;
Fig 4: iron stain shows ringed sideroblasts

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