Chronic Myeloid Neoplasms
MDS / MPN
MDS / MPN - unclassifiable

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 9 March 2017, last major update August 2011

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PubMed Search: MDS/MPN unclassifiable

Cite this page: MDS / MPN - unclassifiable. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/myeloproliferativemdsmpnunclassified.html. Accessed November 23rd, 2017.
Definition / general
  • This is a provisional myelodysplasia / myeloproliferative disorder (Haematologica 2008;93:34, Blood 2006;108:2173), with JAK2 V617F mutation present in 48 - 67%
  • Diagnostic criteria: features of one of the myelodysplasia / myeloproliferative categories but no history of MDS/MPN, no history of growth factor or cytotoxic therapy, no BCR-ABL1 gene fusion, no rearrangement of PDGFRA, PDGFRB or FGFR1, no del(5q), no inv(3)(q21;q26) OR de novo disease with MPN and MDS features which cannot be assigned to any specific category of MDS/MPN
  • Includes refractory anemia with ringed sideroblasts (RARS) with dyserythropoiesis and marked thrombocytosis (RARS-T) with megakaryocytes similar to those in ET, PV or primary myelofibrosis
Case reports
Microscopic (histologic) images

Images hosted on other servers:

Peripheral blood:

Essential thrombocythemia with ringed sideroblasts; Fig 1: peripheral blood shows occasional giant platelets
Fig 2: hypercellular (70%) marrow
Fig 3: clusters of megakaryocytes with hyperlobulation;
Fig 4: iron stain shows ringed sideroblasts