Chronic myeloid neoplasms
Myelodysplastic syndromes
Therapy related myeloid neoplasms

Topic Completed: 1 August 2011

Revised: 18 February 2020

Copyright: 2002-2019,, Inc.

PubMed Search: Therapy related myeloid neoplasm [title]

Nikhil Sangle, M.D.
Page views in 2019: 207
Page views in 2020 to date: 68
Cite this page: Sangle N. Therapy related myeloid neoplasms. website. Accessed April 9th, 2020.
Definition / general
Microscopic (histologic) images

Images hosted on PathOut server:

Peripheral blood:

Post radiochemotherapy and splenectomy
for Hodgkin disease, has hypogranular neutrophil
with pseudo-Pelger-Huet nucleus,
marked poikilocytosis of erythrocytes

Bone marrow smear:

Large erythroid precursors with lobulated nuclei and karyorrhexis


PAS+ erythroid precursors in bone marrow smear

Molecular / cytogenetics description
  • At least 8 alternative genetic pathways
  • Either Class I mutations (activating mutations of genes in tyrosine kinase RAS / BRAF pathway, leading to increased cell proliferation), Class II mutations (inactivating mutations of genes encoding hematopoietic transcription factors, causing disturbed cell proliferation) or inactivating mutations of p53 gene (Hematology Am Soc Hematol Educ Program 2007;392)
Additional references
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