Nasal cavity, paranasal sinuses, nasopharynx
Other malignant tumors
Sinonasal glomangiopericytoma

Topic Completed: 1 November 2004

Minor changes: 27 July 2020

Copyright: 2004-2020,, Inc.

PubMed Search: Glomangiopericytoma

Nat Pernick, M.D.
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Cite this page: Pernick N. Sinonasal glomangiopericytoma. website. Accessed September 30th, 2020.
Definition / general
  • Uncommon tumor of pericytic myoid differentiation (unlike soft tissue hemangiopericytoma)
  • WHO calls it glomangiopericytoma; also called myopericytoma, hemangiopericytoma - sinonasal type (J Laryngol Otol 2007;121:786)
  • Mean age 63 years, usually ages 40+ but range of 5 - 86 years; slight female predominance
  • Usually presents with airway obstruction or epistaxis in nasal cavity or paranasal sinus
  • Recurs locally (18%), no metastases; death due to disease is rare
Case reports
  • Excision plus followup
Gross description
  • Resembles allergic polyp
  • Unilateral, unencapsulated, mean 3 cm, red to gray-pink, soft, edematous, fleshy to friable, often hemorrhagic
Microscopic (histologic) description
  • Diffuse growth with fascicular, solid or focally whorled pattern of spindled or round / oval tumor cells that arrange themselves around prominent, small, thin walled submucosal blood vessels
  • Cells have variable cytoplasm and nuclei, indistinct cell borders, occasionally are multinucleated
  • Minimal atypia, no necrosis, no / rare mitotic activity
  • Vessels are prominent with staghorn appearance and perivascular hyalinization
  • Often mast cells and eosinophils
  • Surface epithelium is intact and usually respiratory
Microscopic (histologic) images

Images hosted on PathOut server:

Bland spindled and round / oval cells with prominent blood vessels

CD34 highlights vessels but tumor cells are negative

Smooth muscle actin is diffusely positive

Images hosted on other servers:

Various images

Negative stains
Electron microscopy description
  • Basal lamina surrounds individual cells, tapered cytoplasmic extensions, orderly bundles of filaments
Electron microscopy images

Images hosted on other servers:

(A) intracytoplasmic thin filaments with dense bodies seen in dendritic thin cytoplasm
occasional intercellular junctions (arrow); irregular basement membrane-like material
(B) tumor cells are separated from capillary; (C) by continuous basement membrane

Differential diagnosis
  • Glomus tumor: also a pericytic tumor with similar staining but extremely rare in sinonasal region, composed of compact epithelioid cells
  • Lobular capillary hemangioma: lobular pattern at low power, has spindled fibroblasts and prominent vessels but overall granulation tissue-like appearance with only small capillaries
  • Solitary fibrous tumor: similar vascular pattern but tumor has patternless pattern, ropy keloidal collagen, thin walled vascular spaces, D2-40- (Virchows Arch 2006;448:459)
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